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| Status |
Public on Aug 23, 2018 |
| Title |
Effect of influenza infection on genome structure in human primary cells [Hi-C] |
| Organism |
Homo sapiens |
| Experiment type |
Other
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| Summary |
Hi-C was used to profile changes in the genome structure of human primary cells at multiple time points in response to infection with active and UV-inactivated H5N1 influenza virus. Human tracheobronchial epithelial cells (HTBE) and monocyte-derived macrophages (MDM) were used. The Influenza A/Vietnam/1203/04 (H5N1) HALo mutant virus is an attenuated H5N1 virus generated from wild-type Influenza A/Vietnam/1203/04 (H5N1) virus as described in Steel, J., et al. J Virol. 2009 Feb; 83(4):1742-53.
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| Overall design |
Human tracheobronchial epithelial cells and monocyte-derived macrophages, obtained from multiple donors, were infected with active and UV-inactivated H5N1 influenza. Samples were collected in duplicate at 6, 12, and 18 hours post-infection for Hi-C analysis, along with time-matched uninfected controls.
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| Contributor(s) |
Benner C, Heinz S, Chang M, Urbanowski M, Pache L, Shaw M, Albrecht R, Garcia-Sastre A |
| Citation(s) |
30146161 |
| Submission date |
Apr 26, 2018 |
| Last update date |
May 10, 2019 |
| Contact name |
Max Chang |
| E-mail(s) |
mchang@ucsd.edu
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| Organization name |
University of California, San Diego
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| Street address |
9500 Gilman Drive
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| City |
La Jolla |
| State/province |
CA |
| ZIP/Postal code |
92093 |
| Country |
USA |
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| Platforms (2) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (36)
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| Relations |
| BioProject |
PRJNA453841 |
| SRA |
SRP143485 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE113703_RAW.tar |
47.2 Gb |
(http)(custom) |
TAR (of HIC) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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