GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE113703 Query DataSets for GSE113703
Status Public on Aug 23, 2018
Title Effect of influenza infection on genome structure in human primary cells [Hi-C]
Organism Homo sapiens
Experiment type Other
Summary Hi-C was used to profile changes in the genome structure of human primary cells at multiple time points in response to infection with active and UV-inactivated H5N1 influenza virus. Human tracheobronchial epithelial cells (HTBE) and monocyte-derived macrophages (MDM) were used. The Influenza A/Vietnam/1203/04 (H5N1) HALo mutant virus is an attenuated H5N1 virus generated from wild-type Influenza A/Vietnam/1203/04 (H5N1) virus as described in Steel, J., et al. J Virol. 2009 Feb; 83(4):1742-53.
Overall design Human tracheobronchial epithelial cells and monocyte-derived macrophages, obtained from multiple donors, were infected with active and UV-inactivated H5N1 influenza. Samples were collected in duplicate at 6, 12, and 18 hours post-infection for Hi-C analysis, along with time-matched uninfected controls.
Contributor(s) Benner C, Heinz S, Chang M, Urbanowski M, Pache L, Shaw M, Albrecht R, Garcia-Sastre A
Citation(s) 30146161
Submission date Apr 26, 2018
Last update date May 10, 2019
Contact name Max Chang
Organization name University of California, San Diego
Street address 9500 Gilman Drive
City La Jolla
State/province CA
ZIP/Postal code 92093
Country USA
Platforms (2)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (36)
GSM3112369 HTBE_12h_H5N1_r1
GSM3112370 HTBE_12h_H5N1_r2
GSM3112371 HTBE_12h_H5N1-UV_r1
BioProject PRJNA453841
SRA SRP143485

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE113703_RAW.tar 47.2 Gb (http)(custom) TAR (of HIC)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap