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Series GSE113703 Query DataSets for GSE113703
Status Public on Aug 23, 2018
Title Effect of influenza infection on genome structure in human primary cells [Hi-C]
Organism Homo sapiens
Experiment type Other
Summary Hi-C was used to profile changes in the genome structure of human primary cells at multiple time points in response to infection with active and UV-inactivated H5N1 influenza virus. Human tracheobronchial epithelial cells (HTBE) and monocyte-derived macrophages (MDM) were used. The Influenza A/Vietnam/1203/04 (H5N1) HALo mutant virus is an attenuated H5N1 virus generated from wild-type Influenza A/Vietnam/1203/04 (H5N1) virus as described in Steel, J., et al. J Virol. 2009 Feb; 83(4):1742-53.
 
Overall design Human tracheobronchial epithelial cells and monocyte-derived macrophages, obtained from multiple donors, were infected with active and UV-inactivated H5N1 influenza. Samples were collected in duplicate at 6, 12, and 18 hours post-infection for Hi-C analysis, along with time-matched uninfected controls.
 
Contributor(s) Benner C, Heinz S, Chang M, Urbanowski M, Pache L, Shaw M, Albrecht R, Garcia-Sastre A
Citation(s) 30146161
Submission date Apr 26, 2018
Last update date Mar 25, 2019
Contact name Max Chang
E-mail mchang@ucsd.edu
Organization name University of California, San Diego
Street address 9500 Gilman Drive
City La Jolla
State/province CA
ZIP/Postal code 92093
Country USA
 
Platforms (2)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (36)
GSM3112369 HTBE_12h_H5N1_r1
GSM3112370 HTBE_12h_H5N1_r2
GSM3112371 HTBE_12h_H5N1-UV_r1
Relations
BioProject PRJNA453841
SRA SRP143485

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE113703_RAW.tar 39.6 Gb (http)(custom) TAR (of HIC)
Raw data are available in SRA
Processed data provided as supplementary file

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