|
| Status |
Public on Apr 17, 2018 |
| Title |
Multi-omics Profiling of Younger Asian Breast Cancers Reveals Distinctive Molecular Signatures |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We observed higher proportions of HER2+ and Luminal B but lower proportions of ER+ and Luminal A subtypes along with lower estrogen receptor (ER) expression in SMC compared to TCGA. Germline pathogenic mutations affecting BRCA1 or BRCA2 were found in 11% of SMC but only 5% of TCGA. TP53 was also more frequently mutated in SMC (48%) than in TCGA (32%).
|
| |
|
| Overall design |
178 samples (168 tumors, 10 normals) from whole transcriptome sequencing
|
| |
|
| Contributor(s) |
Ding Y, Kim J |
| Citation(s) |
29713003 |
| Submission date |
Apr 16, 2018 |
| Last update date |
Jun 13, 2018 |
| Contact name |
YING DING |
| E-mail(s) |
dingying85@gmail.com
|
| Organization name |
Pfizer
|
| Department |
Computational Biology
|
| Street address |
10777 Science Center Dr.
|
| City |
San Diego |
| State/province |
CA |
| ZIP/Postal code |
92121 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL24896 |
Illumina hiseq 2500 (Homo sapiens) |
|
| Samples (178)
|
|
| Relations |
| SRA |
ERP024530 |
| BioProject |
PRJNA450393 |
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