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Series GSE11318 Query DataSets for GSE11318
Status Public on Sep 04, 2008
Title Molecular subtypes of DLBCL have distinct chromosomal aberrations
Organism Homo sapiens
Experiment type Expression profiling by array
Genome variation profiling by genome tiling array
Summary We performed array comparative genomic hybridization (aCGH) and gene expression profiling in 203 samples of diffuse large B cell lymphoma (DLBCL). By gene expression, at least three molecular subtypes of DLBCL termed as germinal center B cell-like (GCB) DLBCL, activated B cell-like (ABC) DLBCL, and primary mediastinal B cell lymphoma (PMBL) can be distinguished. Combining gene expression profiling and aCGH, revealed copy number abnormalities that had strikingly different frequencies in the three molecular DLBCL subtypes. These data provide genetic evidence that the DLBCL subtypes are distinct diseases that utilize different oncogenic pathways.
Keywords: clinical history design
 
Overall design The retrospective study included RNA and DNA extracted from 203 clinical samples.
 
Citation(s) 18765795
Submission date May 01, 2008
Last update date Jan 08, 2019
Contact name Louis M. Staudt
E-mail lstaudt@mail.nih.gov
Phone 301-402-1892
Organization name National Cancer Institute
Department Lymphoid Malignancies Branch
Lab Louis M Staudt
Street address 9000 Rockville Pike, Bldg 10, Rm 4N114
City Bethesda
State/province MD
ZIP/Postal code 20892
Country USA
 
Platforms (2)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
GPL6400 NCI NimbleGen Homo sapiens HG17 Whole Genome 385K Tiling Set version 1
Samples (406)
GSM274895 549 - mAdbID:65792
GSM274896 553 - mAdbID:65793
GSM274897 689 - mAdbID:65794
Relations
BioProject PRJNA106631

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE11318_RAW.tar 3.2 Gb (http)(custom) TAR (of CEL, TXT)
Raw data provided as supplementary file
Processed data included within Sample table

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