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Series GSE11291 Query DataSets for GSE11291
Status Public on Jun 10, 2008
Title Effect of age, calorie restriction and resveratrol on gene expression in mouse heart, brain, and skeletal muscle
Organism Mus musculus
Experiment type Expression profiling by array
Summary Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose of resveratrol (4.9 mg kg-1 day-1), or a calorie restricted (CR) diet and examined genome-wide transcriptional profiles.
We report a striking transcriptional overlap of CR and resveratrol in heart, skeletal muscle and brain. Both dietary interventions inhibit gene expression profiles associated with cardiac and skeletal muscle aging. Gene expression profiling suggests that both CR and resveratrol may retard some aspects of aging through alterations in chromatin structure and transcription. Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some aspects of CR.
Keywords: aging intervention study
Overall design Heart, neocortex tissue, and gastrocnemius muscle was collected from young and old mice at 5 and 30 months of age, respectively; mice were subjected to either a calorie restricted diet or a control diet supplemented with resveratrol
Contributor(s) Barger JL
Citation(s) 18523577
Submission date Apr 29, 2008
Last update date Feb 11, 2019
Contact name Jamie Barger
Organization name LifeGen Technologies, LLC
Street address 510 Charmany Drive, Suite 263
City Madison
State/province WI
ZIP/Postal code 53719
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (60)
GSM284967 heart-5 months of age-control diet-biological replicate1
GSM284968 heart-5 months of age-control diet-biological replicate2
GSM284969 heart-5 months of age-control diet-biological replicate3
BioProject PRJNA106707

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE11291_RAW.tar 226.8 Mb (http)(custom) TAR (of CEL, CHP)
Raw data provided as supplementary file
Processed data included within Sample table
Processed data provided as supplementary file

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