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Series GSE112414 Query DataSets for GSE112414
Status Public on Mar 28, 2019
Title Chromatin interaction of ERG and AR in established prostate cancer
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary The current study defines the how ERG, PTEN, and AR inteact to regulate the transciptome in established prostate cancers. Prostate cancer organoids were derived from established prostate cancer in GEM models harboring ERG over-expression and/or loss of PTEN and cultured in vitro using prostate epithelial organoid culture conditions. The established organoids were then isolated as individual clones in triplicate and CRISPR strategies were employeed to knock out ERG and AR. ChIP seq was performed under standard growth and media conditions.
 
Overall design 12 samples with 3 genotype in 4 conditions
 
Contributor(s) Carver BS
Citation(s) 31296553
Submission date Mar 28, 2018
Last update date May 20, 2021
Contact name WENHUO HU
E-mail(s) huwenhuo@gmail.com, huw@mskcc.org
Phone 6468882468
Organization name MEMORIAL SLOAN KETTERING CANCER CENTER
Department HOPP
Lab Christopher Park
Street address 1275 YORK AVENUE
City NEW YORK
State/province NEW YORK
ZIP/Postal code 10065
Country USA
 
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (9)
GSM3069709 AR_Crispr_818PTEN_ERG_ARIP
GSM3069710 AR_Crispr_818PTEN_ERG_ERGIP
GSM3069711 AR_Crispr_818PTEN_ERG_H3K27AcIP
Relations
BioProject PRJNA445955
SRA SRP136603

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE112414_RAW.tar 2.3 Gb (http)(custom) TAR (of BW)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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