|
| Status |
Public on Dec 11, 2019 |
| Title |
Deep transcriptomic analysis of human vascular cells identifies novel risk genes for common vascular diseases |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Several genome-wide association studies have to date been carried out to identify genetic risk loci associated with vascular diseases. Many of the established common variants likely perturb the expression of disease-relevant genes within the vascular tissue itself. To identify such genes on a genome-wide level, we analyzed the transcriptome of human coronary artery smooth muscle and endothelial cells for Allele-Specific Expression (ASE).
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| |
|
| Overall design |
observation of mRNA expression in 2 different cell types from paired donor samples
|
| |
|
| Contributor(s) |
Brown CD, Quertermous T, Rader DJ |
| Citation(s) |
31917787 |
| Submission date |
Feb 26, 2018 |
| Last update date |
Feb 10, 2020 |
| Contact name |
Sylvia T Nurnberg |
| E-mail(s) |
sylvian@upenn.edu
|
| Organization name |
University of Pennsylvania
|
| Department |
Medicine
|
| Lab |
Rader
|
| Street address |
3400 Civic Center Blvd
|
| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19104 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (38)
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|
| Relations |
| BioProject |
PRJNA435966 |
| SRA |
SRP133483 |
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