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Series GSE111009 Query DataSets for GSE111009
Status Public on Feb 11, 2019
Title Cell type-dependent control of enhancer and p53 transcriptional activity by p63
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Summary In this work, we demonstrate that the p53-induced transcriptome is dependent on pre-establishment of cell type-dependent cis-regulatory networks. The epithelial-specific p53 transcriptome is strongly dependent on p63, which acts as a pioneer factor for epithelial-specific enhancers. These results suggest a broad mechanism for regulating the p53-dependent cellular response to stress through differential regulation of cis-regulatory elements and identify p63 as a direct and critical regulator of enhancer activity in epithelial cell types.
 
Overall design p53 transcriptome: RNA-Seq and ChIP-Seq
 
Contributor(s) Sammons MA, Ahmed FA, Karsli Uzunbas G
Citation(s) 31113863, 38766006
NIH grant(s)
Grant ID Grant title Affiliation Name
R15 GM128049 Molecular mechanisms regulating the establishment of cis-regulatory elements by the transcription factor p63 UNIVERSITY AT ALBANY, SUNY Morgan Andrew Sammons
Submission date Feb 22, 2018
Last update date May 30, 2024
Contact name Morgan A Sammons
E-mail(s) masammons@albany.edu
Organization name University at Albany - SUNY
Department Biological Sciences
Lab Sammons
Street address 1400 Washington Ave, Life Sciences 2075
City Albany
State/province NY
ZIP/Postal code 12222
Country USA
 
Platforms (2)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (98)
GSM3020073 RNAseq-Skin Fibroblast-treated with DMSO-1
GSM3020074 RNAseq-Skin Fibroblast-treated with DMSO-2
GSM3020075 RNAseq-Skin Fibroblast-treated with DMSO-3
Relations
BioProject PRJNA435584
SRA SRP133299

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Supplementary file Size Download File type/resource
GSE111009_RAW.tar 854.0 Mb (http)(custom) TAR (of BED, BEDGRAPH, BW, NARROWPEAK, TXT)
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Raw data are available in SRA
Processed data provided as supplementary file
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