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Series GSE110912 Query DataSets for GSE110912
Status Public on Jul 08, 2019
Title Effect of TGFb1 treatment and WISP1 overexpression on 4T1 breast cancer cells
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary This study set out to identify TGFb1 transcriptional targets in breast cancer cells. 4T1 breast cancer cells were treated with TGFb1 for 24h and transcripts that were significantly regulated were identified. Wisp1 was identified as one of the genes most highly upregulated by TGFb1. To identify the transcriptional targets of Wisp1, 4T1 cells were then virally transduced to increase Wisp1 expression. The gene expression profiles of Wisp1-overexpressing 4T1 cells were determined and revealed that Wisp1 overexpression does not result in major gene expression changes in 4T1 cells.
Overall design mRNA profiles from 4T1 breast cancer cells treated with TGFb1 or with Wisp1 overexpression were examined.
Contributor(s) Finkelstein D, Labelle M
Citation(s) 31294477
Submission date Feb 21, 2018
Last update date Aug 09, 2019
Contact name David Finkelstein
Phone 9014953931
Organization name St Jude Children's Research Hospital
Department Computational Biology
Street address 332 N. Lauderdale St.
City Memphis
State/province TN
ZIP/Postal code 38105
Country USA
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (18)
GSM3018726 SJMMBRCA054934_C1-HJ496_1-4T1
GSM3018728 SJMMBRCA054934_C2-HJ497_1-4T1
GSM3018733 SJMMBRCA054934_C3-HJ510_1-4T1
BioProject PRJNA434801
SRA SRP133203

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE110912_RAW.tar 2.4 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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