|
| Status |
Public on Aug 06, 2019 |
| Title |
Metabolic reprogramming of macrophage polarization by creatine [RNA-seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We found that the creatine metabolic pathway was differentially regulated under M1 versus M2 polarizing conditions. In return, creatine could suppress M1 by blocking STAT1 tyrosine phosphorylation while promote M2 by sustaining chromatin accessibility of specific gene loci.
|
| |
|
| Overall design |
Analyze the changes of transcriptomes in macrophages lack of creatine during macrophage polarization
|
| |
|
| Contributor(s) |
Ji L, Zhao X |
| Citation(s) |
31399282 |
| |
| Submission date |
Feb 09, 2018 |
| Last update date |
Nov 05, 2019 |
| Contact name |
Liangliang Ji |
| E-mail(s) |
jll14@mails.tsinghua.edu.cn
|
| Organization name |
Institute for Immunology
|
| Department |
School of Medicine
|
| Lab |
Xiaoyu Hu
|
| Street address |
Tsinghua University
|
| City |
Beijing |
| ZIP/Postal code |
100084 |
| Country |
China |
| |
|
| Platforms (1) |
|
| Samples (8)
|
|
| This SubSeries is part of SuperSeries: |
| GSE110456 |
Metabolic reprogramming of macrophage polarization by creatine |
|
| Relations |
| BioProject |
PRJNA433621 |
| SRA |
SRP132551 |
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