|
| Status |
Public on Mar 12, 2018 |
| Title |
Analysis of Th17 gene signature in the presence of CD28 costimulation in human CD4 naïve T cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We determined differentially regulated gene expression profile in CD4 naïve T cells cultured in presence or absence of Th17 inducing cytokines (IL23+IL1β) and anti-CD28. We reported that CD28 costimulation induced Th17-suppressive gene signature.
|
| |
|
| Overall design |
Human CD4 naive T cells were cultured as 4 different conditions (Th0, Th0CD28, Th17 and Th17CD28) to examine differentially expressed genes among conditions.
|
| |
|
| Contributor(s) |
Revu S, McGeachy M, Rittenhouse N, Poholek A |
| Citation(s) |
29514093 |
| |
| Submission date |
Feb 02, 2018 |
| Last update date |
Mar 26, 2019 |
| Contact name |
Amanda Catherine Poholek |
| E-mail(s) |
poholeka@pitt.edu
|
| Organization name |
University of Pittsburgh
|
| Department |
Pediatrics
|
| Street address |
4401 Penn Ave., Rangos Research Center 8129
|
| City |
Pittsburgh |
| State/province |
Pennsylvania |
| ZIP/Postal code |
15224 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (13)
|
|
| Relations |
| BioProject |
PRJNA432744 |
| SRA |
SRP132102 |
Less...
More...