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Series GSE109820 Query DataSets for GSE109820
Status Public on Jan 30, 2018
Title Early dynamics of ERa and GRHL2 binding on stimulation with estradiol
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary We measured ER binding by ChIP-Seq at three time-points (0, 45, 90 minutes after activation with E2) and overlaid the binding information on a co-expression network. Our approach, called VULCAN, rediscovered many known components of the ER complex and additionally found that the activation ER results in the reprogramming of the transcriptional role of the GRHL2 cofactor.
 
Overall design ChIP-seq data in MCF7 at three time-points for ERa and two time points for GRHL2 after stimulation with 100 nM E2
 
Contributor(s) Holding AN, Markowetz F
Citation(s) 31084623
Submission date Jan 29, 2018
Last update date Jun 18, 2019
Contact name Andrew Nicholas Holding
E-mail(s) andrew.holding@cruk.cam.ac.uk
Organization name University of Cambridge
Department CRUK Cambridge Institute
Street address Robinson Way
City Cambridge
ZIP/Postal code CB2 0RE
Country United Kingdom
 
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (36)
GSM2970402 ER_Ctrl_1
GSM2970403 ER_E2_45min_1
GSM2970404 ER_E2_90min_1
Relations
BioProject PRJNA432085
SRA SRP131759

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE109820_RAW.tar 7.0 Mb (http)(custom) TAR (of BED, NARROWPEAK)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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