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| Status |
Public on Mar 03, 2019 |
| Title |
The epigenome and glucocorticoid receptor binding of human monocytes and monocyte-derived macrophages with or without glucocorticoid treatment |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Glucocorticoids (GCs) are essential steroid hormones that regulate the immune system. GCs have been widely used to treat various inflammation disorders and auto-immune diseases due to their potent immune suppressive properties.
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| Overall design |
Monocytes from healthy donors and the respective monocyte-derived macrophages were cultured in the presence of triamcinolone acetonide (TA) for 4 hours. Cells were then collected for ChIP-seq.
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| Contributor(s) |
Wang C, Colin L |
| Citation(s) |
30809020 |
| |
| Submission date |
Jan 19, 2018 |
| Last update date |
Mar 26, 2019 |
| Contact name |
Cheng Wang |
| E-mail(s) |
jxwangcheng@gmail.com
|
| Phone |
+31243610533
|
| Organization name |
Radboud Institute for Molecular Life Sciences
|
| Department |
Molecular biology
|
| Street address |
Geert Grooteplein 28
|
| City |
Nijmegen |
| ZIP/Postal code |
6525 GA |
| Country |
Netherlands |
| |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (32)
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| This SubSeries is part of SuperSeries: |
| GSE109440 |
Extensive epigenomic integration of the glucocorticoid response in primary human monocytes and in vitro derived macrophages |
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| Relations |
| BioProject |
PRJNA430885 |
| SRA |
SRP131051 |
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