|
| Status |
Public on Dec 01, 2019 |
| Title |
TIP60 represses activation of endogenous retroviral elements |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We found that the loss of TIP60 de-represses retrotransposon elements genome-wide, which in turn activate the cellular response to pathogens mediated by STING, culminating in an induction of Interferon Regulatory Factor 7 (IRF7) and associated inflammatory response.
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| |
|
| Overall design |
SRA accession: SRP128080 ; BioProject accession: PRJNA428558
|
| |
|
| Contributor(s) |
Rajagopalan D, Jha S |
| Citation missing |
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| BioProject |
PRJNA428558 |
| |
| Submission date |
Jan 05, 2018 |
| Last update date |
Dec 01, 2019 |
| Contact name |
Roberto Tirado-Magallanes |
| E-mail(s) |
e0056363@nus.edu.sg, rtmag4@gmail.com
|
| Organization name |
Cancer Science Institute of Singapore
|
| Street address |
14 Medical Dr
|
| City |
Singapore |
| State/province |
Singapore |
| ZIP/Postal code |
117599 |
| Country |
Singapore |
| |
|
| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
|
| Samples (8)
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|
| Relations |
| SRA |
SRP128080 |
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