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Series GSE108211 Query DataSets for GSE108211
Status Public on May 26, 2020
Title Blood genome expression Profiles in Infants with Congenital Cytomegalovirus Infection: Is the asymptomatic infant truly asymptomatic?
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Background: Congenital cytomegalovirus (cCMV) infection represents the most frequent non-genetic cause of sensorineural hearing loss (SNHL). The disease spectrum varies from clinically apparent (“symptomatic”) to clinically inapparent (“asymptomatic”). Analysis of host genome expression profiles has provided new insights into disease pathogenesis and assessment of clinical severity. Its value as a biomarker in infants with cCMV has not been explored. Methods: Infants with cCMV infection, both symptomatic and asymptomatic, were enrolled at a median age of 17 days of age and followed up for 3 years to assess the development of SNHL. Healthy age matched controls were also enrolled as a reference. Blood samples were obtained at enrollment and follow-up to assess host responses by RNA transcriptional profiling. Symptomatic CMV was defined as the presence of any clinical, laboratory, ophthalmologic, audiologic or neuroimaging abnormalities.
 
Overall design 158 total samples; 56 Asymptomatic; 92 Symptomatic; 10 Control
 
Contributor(s) Ouellette C, Sanchez PJ, Zeray F, Ronchi A, Jaramillo L, Shimamura M, Ramilo O, Mejias A
Citation(s) 32669541
Submission date Dec 18, 2017
Last update date Mar 16, 2023
Contact name Nicole Baldwin
E-mail(s) Nicole.Baldwin@BSWHealth.org
Organization name Baylor Research Institute
Street address 3434 Live Oak St
City Dallas
ZIP/Postal code 75204
Country USA
 
Platforms (1)
GPL10558 Illumina HumanHT-12 V4.0 expression beadchip
Samples (158)
GSM2892336 whole blood-Asymptomatic-1_9970511001_H
GSM2892337 whole blood-Asymptomatic-2_9970511001_D
GSM2892338 whole blood-Asymptomatic-3_9970511001_C
Relations
BioProject PRJNA422858

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE108211_RAW.tar 26.2 Mb (http)(custom) TAR
GSE108211_non-normalized_data_47231_probes.txt.gz 728.4 Kb (ftp)(http) TXT
GSE108211_non-normalized_data_47323_probes.txt.gz 37.2 Mb (ftp)(http) TXT
Processed data included within Sample table
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