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| Status |
Public on Jun 05, 2018 |
| Title |
Single-cell RNA sequencing resolves cellular heterogeneity throughout embryonic development of the thymus |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
This dataset consists of single-cell RNA-seq (Drop-seq) data from eight days of mouse thymus development. Samples span from embryonic day 12.5, when the thymus coalesces, until birth. They cover the whole thymus, including mesenchyme, endothelium, epithelium, thymocytes, and other lymphocytes. The dataset also includes Drop-seq data on Rag1-/- embryos and on fetal thymic organ cultures (control and a retinoic acid perturbation).
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| Overall design |
A single-cell atlas of the developing mouse thymus.
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| Contributor(s) |
Kernfeld E, Genga R, Magaletta M, Neherin K, Xu P, Maehr R |
| Citation(s) |
29884461 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| DP3 DK111898 |
Deciphering the molecular basis of T1D in human cells using functional genomics |
President and Fellows of Harvard College |
Rene Maehr |
| R01 AI132963 |
Novel humanized mouse model developed from cord blood CD34 positive HSC and autologous iPS cell derived thymus |
UNIV OF MASSACHUSETTS MED SCHOOL |
Rene Maehr |
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| |
| Submission date |
Dec 11, 2017 |
| Last update date |
Oct 11, 2019 |
| Contact name |
Rene Maehr |
| Organization name |
UMass Medical School
|
| Department |
Program in Molecular Medicine
|
| Lab |
Diabetes Center of Excellence
|
| Street address |
55 Lake Ave N
|
| City |
Worcester |
| State/province |
MA |
| ZIP/Postal code |
01604 |
| Country |
USA |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (27)
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| Relations |
| BioProject |
PRJNA421909 |
| SRA |
SRP126497 |
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