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| Status |
Public on Feb 01, 2018 |
| Title |
PBMC gene expression from Crohn's disease patients before Infliximab therapy. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
About 40% IBD patients treated with anti-TNF antibodies do not respond to therapy. Baseline biomarkers of response are therefore of interest. By combining computational deconvolution of gene expression and meta-analysis approaches we identified cellular biomarkers in tissue (validated in 2 cohorts by IHC of biopsies), and investigated associated gene biomarkers in blood. This dataset provides data from the validation cohort III (blood).
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| Overall design |
Whole blood samples were collected from 22 patients diagnosed with Crohn's disease, just before starting anti-TNF therapy (Infliximab). All patients were naive to anti-TNF. Response to therapy was assessed after 14 weeks based on changes in CRP and Calprotectin, as well as endoscopy (Responders: 17; Non-responders: 5). The prognostic power of genes identified to be related to cellular biomarkers identified from meta-analysis of public datasets of biopsy tissues were investigated.
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| Contributor(s) |
Gaujoux R, Starosvetsky E, Maimon N, Vallania F, Chowers Y, Khatri P, Shen-Orr SS |
| Citation(s) |
29618496 |
| |
| Submission date |
Dec 08, 2017 |
| Last update date |
Feb 01, 2019 |
| Contact name |
Shai S Shen-Orr |
| E-mail(s) |
shenorr@technion.ac.il
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| Organization name |
Rappaport Institute of Medical Research, Faculty of Medicine and Faculty of Biology, Technion
|
| Department |
Immunology
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| Lab |
Systems Immunology
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| Street address |
1st Efron Street
|
| City |
Haifa |
| ZIP/Postal code |
32000 |
| Country |
Israel |
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| Platforms (1) |
| GPL23159 |
[Clariom_S_Human] Affymetrix Clariom S Assay, Human (Includes Pico Assay) |
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| Samples (22)
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| Relations |
| BioProject |
PRJNA421740 |
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