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Series GSE10784 Query DataSets for GSE10784
Status Public on Apr 10, 2008
Title Gene profile data from Df(16)A/+ and wild type littermates
Organism Mus musculus
Experiment type Expression profiling by array
Summary This represents an unbiased evaluation of the transcriptional response in the prefrontal cortex and hippocampus areas in the Df(16)A/+ mice, a mouse model of human 22q11 microdeletion syndrome. These mice were generated by chromosomal engineering and carry a microdeltion of ~1.3Mb in the mouse locus syntenic to the human 22q11.1
The reasoning behind this expression profiling is that alterations in transcriptional programs reflect either downstream (immediate or remote) effects of the deficiency or reactive (compensatory) changes, and can thus point to affected biological processes and molecular functions.
Keywords: disease state analysis, genetic modification
Overall design A total of 20 PFC and 20 HPC from 10 Df(16)A/+ mutants and 10 WT control mice was used for RNA extraction and hybridization on Affymetrix microarrays. All mice were male littermates 8 weeks of age.
Contributor(s) Stark KL, Xu B, Karayiorgou M, Gogos JA
Citation(s) 18469815, 23332760
Submission date Mar 11, 2008
Last update date Feb 11, 2019
Contact name Joseph Gogos
Organization name Columbia University
Department Physiology
Street address 630 W 168 st P&S 11-519
City New York
State/province NY
ZIP/Postal code 10032
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (40)
GSM272324 Df(16)A/+_PFC, biological replicate 1
GSM272325 wt_PFC, biological replicate 1
GSM272326 wt_PFC, biological replicate 2
BioProject PRJNA107471

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE10784_RAW.tar 255.9 Mb (http)(custom) TAR (of CEL, EXP)
Raw data provided as supplementary file
Processed data included within Sample table

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