|
| Status |
Public on Jun 30, 2020 |
| Title |
Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer (RNA-Seq) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Metastasis is the cause of death for 90% of cancer patients, but little is known about how cancer cells adapt to and colonize new tissue environments. Using clinical samples and primary/metastatic cell lines, we found metastatic colorectal cancer (CRC) cells lose their colon-specific gene transcription program and gain a liver-specific gene transcription program as they metastasize in the liver. We revealed this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical and super-enhancers. Further, we identified FOXA2, a liver-specific transcription factor, plays a key role in this transcription reprogramming and the colonization of metastatic CRC cells in the liver. Notably, this transcription reprogramming is also observed in multiple cancer types. Our data demonstrate that epigenetically reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically.
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| |
|
| Overall design |
Examination of 4 different histone modifications and transcriptome in 2 cell lines.
|
| |
|
| Contributor(s) |
Li YE, Teng S |
| Citation(s) |
31811277 |
| |
| Submission date |
Nov 15, 2017 |
| Last update date |
Sep 29, 2020 |
| Contact name |
Yang Eric Li |
| E-mail(s) |
liyang01133@gmail.com
|
| Phone |
+1-8589222580
|
| Organization name |
Tsinghua University
|
| Department |
School of Life Sciences
|
| Lab |
Zhi John Lu
|
| Street address |
Room 2-110, Biotechnology Building, School of Life Sciences, Tsinghua University
|
| City |
Beijing |
| State/province |
Beijing |
| ZIP/Postal code |
100084 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL18460 |
Illumina HiSeq 1500 (Homo sapiens) |
|
| Samples (8)
|
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| This SubSeries is part of SuperSeries: |
| GSE106923 |
Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer |
|
| Relations |
| BioProject |
PRJNA418656 |
| SRA |
SRP125123 |
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