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Series GSE106657 Query DataSets for GSE106657
Status Public on Mar 07, 2018
Title Simultaneous host-pathogen transcriptional analysis of Clostridium perfringens murine myonecrosis infections
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary To obtain an insight into host-pathogen interactions in clostridial myonecrosis, we carried out comparative RNA-seq analysis measuring host genes in a murine C. perfringens infection model. Analysis of the murine transcriptome from infected muscle tissues indicated that 270 genes were up-regulated compared to control mock-infected mice. KEGG pathway analysis of these genes revealed an enrichment of Toll-like receptor (TLR) and Nod-like receptor (NLR) signaling components.
 
Overall design Examination of host gene expression 1.5 hours after infection or mock-infection (control) with Clostridium perfringens in triplicate using the AB SOLiD system.
 
Contributor(s) Low L, Harrison PF, Gould J, Powell DR, Choo JM, Forster S, Chapman R, Cheung JK, Hertzog P, Rood JI
Citation(s) 29588405
Submission date Nov 08, 2017
Last update date May 15, 2019
Contact name Jamie Gearing
Organization name Hudson Institute of Medical Research
Street address 27-31 Wright St
City Melbourne
ZIP/Postal code 3168
Country Australia
 
Platforms (1)
GPL15907 AB 5500xl Genetic Analyzer (Mus musculus)
Samples (6)
GSM2844604 PBS1 rep1
GSM2844605 PBS2 rep1
GSM2844606 PBS3 rep3
Relations
BioProject PRJNA417557
SRA SRP124586

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE106657_RAW.tar 1.2 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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