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Status |
Public on Mar 07, 2018 |
Title |
Simultaneous host-pathogen transcriptional analysis of Clostridium perfringens murine myonecrosis infections |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
To obtain an insight into host-pathogen interactions in clostridial myonecrosis, we carried out comparative RNA-seq analysis measuring host genes in a murine C. perfringens infection model. Analysis of the murine transcriptome from infected muscle tissues indicated that 270 genes were up-regulated compared to control mock-infected mice. KEGG pathway analysis of these genes revealed an enrichment of Toll-like receptor (TLR) and Nod-like receptor (NLR) signaling components.
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Overall design |
Examination of host gene expression 1.5 hours after infection or mock-infection (control) with Clostridium perfringens in triplicate using the AB SOLiD system.
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Contributor(s) |
Low L, Harrison PF, Gould J, Powell DR, Choo JM, Forster S, Chapman R, Cheung JK, Hertzog P, Rood JI |
Citation(s) |
29588405 |
Submission date |
Nov 08, 2017 |
Last update date |
May 15, 2019 |
Contact name |
Jamie Gearing |
Organization name |
Hudson Institute of Medical Research
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Street address |
27-31 Wright St
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City |
Melbourne |
ZIP/Postal code |
3168 |
Country |
Australia |
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Platforms (1) |
GPL15907 |
AB 5500xl Genetic Analyzer (Mus musculus) |
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Samples (6)
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Relations |
BioProject |
PRJNA417557 |
SRA |
SRP124586 |