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Series GSE106643 Query DataSets for GSE106643
Status Public on Jul 01, 2019
Title The olfactory molecular snapshot of Tg2576 mice at early stages of amyloid pathology
Organism Mus musculus
Experiment type Expression profiling by array
Summary Olfaction is often deregulated in Alzheimer's disease (AD) patients, being also impaired in transgenic Tg2576 AD mouse model, which overexpress the Swedish mutated form of human amyloid precursor protein (APP). However, little is known about the molecular mechanisms that accompany the neurodegeneration of olfactory structures in Tg2576 mice. For that, we have applied proteome- and transcriptome-wide approaches to probe molecular disturbances in the olfactory bulb (OB) dissected from Tg2576 mice (2, and 6 months of age) respect to age-matched wild-type (WT) littermates.
 
Overall design Olfactory bulbs from 3 WT mice vs. olfactory bulbs from 3 Tg2576 transgenic mice in each time point.
 
Contributor(s) Santamaría E
Citation(s) 31244650
Submission date Nov 07, 2017
Last update date Jul 01, 2019
Contact name Victor Segura
E-mail(s) vsegura@unav.es
Organization name FIMA
Department Unit of Proteomics, Genomics and Bioinformatics
Street address Avda. Pío XII, 55
City Pamplona
State/province Navarra
ZIP/Postal code 31008
Country Spain
 
Platforms (1)
GPL23038 [Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay)
Samples (12)
GSM2844218 OB_TG2576_2M_R1
GSM2844219 OB_TG2576_2M_R2
GSM2844220 OB_TG2576_2M_R3
Relations
BioProject PRJNA417496

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE106643_RAW.tar 14.6 Mb (http)(custom) TAR (of CEL)
SRA Run SelectorHelp
Raw data provided as supplementary file
Processed data included within Sample table

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