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| Status |
Public on Dec 31, 2018 |
| Title |
TET2 regulates the neuroinflammatory response in microglia |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Epigenetic mechanisms regulate distinct aspects of the inflammatory response in various immune cell types. Despite a central role for microglia in neuroinflammation and neurodegeneration little is known about their epigenetic regulation of the inflammatory response. We found that TET2 expression is increased in microglia upon stimulation with various inflammogens through a NF-kB-dependent pathway. RNA-seq analysis showed that TET2 modulates the transcriptional response of microglial cells to LPS.
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| Overall design |
TET2-depleted or control microglial BV2 cells were treated with LPS for 3 hours.
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| Contributor(s) |
Carrillo-Jimenez A, Deniz O, Niklison-Chirou M, Bezerra-Salomao K, Stratoulias V, Amouroux R, Ruiz R, Yip P, Vilalta A, Cheray M, Scott-Egerton A, Rivas E, Tayara K, Espinosa-Oliva AM, Shen X, Brown G, Hajkova P, Joseph B, Venero J, Branco M, Burguillos MA |
| Citation(s) |
31618637 |
| Submission date |
Oct 19, 2017 |
| Last update date |
Nov 04, 2019 |
| Contact name |
Miguel R Branco |
| E-mail(s) |
m.branco@qmul.ac.uk
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| Organization name |
Blizard Institute
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| Street address |
4 Newark Street
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| City |
London |
| ZIP/Postal code |
E1 2AT |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (11)
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| Relations |
| BioProject |
PRJNA414973 |
| SRA |
SRP120491 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE105155_gene_expression_vsd.txt.gz |
953.5 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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