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Series GSE105155 Query DataSets for GSE105155
Status Public on Dec 31, 2018
Title TET2 regulates the neuroinflammatory response in microglia
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Epigenetic mechanisms regulate distinct aspects of the inflammatory response in various immune cell types. Despite a central role for microglia in neuroinflammation and neurodegeneration little is known about their epigenetic regulation of the inflammatory response. We found that TET2 expression is increased in microglia upon stimulation with various inflammogens through a NF-kB-dependent pathway. RNA-seq analysis showed that TET2 modulates the transcriptional response of microglial cells to LPS.
Overall design TET2-depleted or control microglial BV2 cells were treated with LPS for 3 hours.
Contributor(s) Carrillo-Jimenez A, Deniz O, Niklison-Chirou M, Bezerra-Salomao K, Stratoulias V, Amouroux R, Ruiz R, Yip P, Vilalta A, Cheray M, Scott-Egerton A, Rivas E, Tayara K, Espinosa-Oliva AM, Shen X, Brown G, Hajkova P, Joseph B, Venero J, Branco M, Burguillos MA
Citation(s) 31618637
Submission date Oct 19, 2017
Last update date Nov 04, 2019
Contact name Miguel R Branco
Organization name Blizard Institute
Street address 4 Newark Street
City London
ZIP/Postal code E1 2AT
Country United Kingdom
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (11)
GSM2823400 BV2_siScr_Ctrl-1
GSM2823401 BV2_siScr_Ctrl-2
GSM2823402 BV2_siScr_Ctrl-3
BioProject PRJNA414973
SRA SRP120491

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Supplementary file Size Download File type/resource
GSE105155_gene_expression_vsd.txt.gz 953.5 Kb (ftp)(http) TXT
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