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Series GSE104725 Query DataSets for GSE104725
Status Public on Oct 10, 2017
Title Quantitative Transcriptome Analysis of T cells stimulated with STING ligands
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary STING plays a key role in detecting cytosolic DNA and induces type I interferon responses for host defense against pathogens. Although T cells highly express STING, its physiological role remains unknown. In this study, we show that costimulation of T cells via TCR and STING ligand induce type I IFN responses like innate immune cells.
 
Overall design Naïve CD4+ T cells were stimulated with anti-CD3/28 in the presence or absence of STING ligand and analyzed the transcriptome using Illumina HiSeq1500.
 
Contributor(s) Imanishi T, Saito T
Citation(s) 30683688
Submission date Oct 09, 2017
Last update date May 15, 2019
Contact name Takayuki Imanishi
E-mail(s) takayuki.imanishi@riken.jp
Organization name RIKEN Center for Integrative Medical Sciences (IMS)
Street address 1-7-22 Suehiro-cho, Tsurumi-ku
City Yokohama
ZIP/Postal code 230-0045
Country Japan
 
Platforms (1)
GPL18480 Illumina HiSeq 1500 (Mus musculus)
Samples (10)
GSM2806686 Naive CD4_1
GSM2806687 Naive CD4_2
GSM2806688 CD3/28_3h_1
Relations
BioProject PRJNA413658
SRA SRP119595

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE104725_RAW.tar 1.4 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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