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Series GSE104630 Query DataSets for GSE104630
Status Public on Apr 05, 2018
Title Innate immune memory in the brain shapes neurological disease hallmarks [RNA-seq]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Innate immune memory is a vital mechanism of myeloid cell plasticity that occurs in response to environmental stimuli and alters subsequent immune responses. Two types of immunological imprinting can be distinguished—training and tolerance. These are epigenetically mediated and enhance or suppress subsequent inflammation, respectively. Whether immune memory occurs in tissue-resident macrophages in vivo and how it may affect pathology remains largely unknown. Here we demonstrate that peripherally applied inflammatory stimuli induce acute immune training and tolerance in the brain and lead to differential epigenetic reprogramming of brain-resident macrophages (microglia) that persists for at least six months. Strikingly, in a mouse model of Alzheimer’s pathology, immune training exacerbates cerebral beta-amyloidosis and immune tolerance alleviates it; similarly, peripheral immune stimulation modifies pathological features after stroke. Our results identify immune memory in the brain as an important modifier of neuropathology.
Overall design mRNA was isolated from FACS-purified microglia and prepared for RNA-sequencing.
Contributor(s) Neher JJ, Fischer A, Ulas T
Citation(s) 29643512
Submission date Oct 05, 2017
Last update date May 15, 2019
Contact name Jonas J Neher
Organization name German Center for Neurodegenerative Diseases (DZNE) Tübingen
Department Experimental Neuroimmunology
Street address Otfried Mueller Str. 23
City Tübingen
ZIP/Postal code 72076
Country Germany
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (39)
GSM2804336 APP 1xLPS1
GSM2804337 APP 1xLPS2
GSM2804338 APP 1xLPS3
This SubSeries is part of SuperSeries:
GSE82170 Innate immune memory in the brain shapes neurological disease hallmarks
BioProject PRJNA413371
SRA SRP119455

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE104630_Gene-expression-matrix.xlsx 4.5 Mb (ftp)(http) XLSX
GSE104630_WGCNA.xlsx 4.4 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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