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Series GSE104545 Query DataSets for GSE104545
Status Public on Mar 01, 2018
Title The ARID1A tumor suppressor controls global transcription via pausing of RNA Polymerase II
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Other
Summary We investigated the genomic consequences of the depletion of the SWI/SNF subumit ARID1A, in an ovarian cancer derived model. We produced genome wide data for nascent RNA (GRO-seq) and steady state RNA (total RNA-seq). Further, we used ChIP-seq to examine genome-wide distribution of ARID1A, as well as the changes in occupancy of RNAPII, H3K4me3 and H3K36me3. Finally we used ATAC-seq to investigate chromatin accessibility.
 
Overall design Analysis of global transcriptional changes associated to the depletion of ARID1A.
 
Contributor(s) Trizzino M, Barbieri E, Petracovici A, Wu S, Welsh S, Owens T, Licciulli S, Zhang R, Gardini A
Citation(s) 29949775
Submission date Oct 03, 2017
Last update date Mar 26, 2019
Contact name Marco Trizzino
E-mail(s) marco.trizzino83@gmail.com
Phone 4845983902
Organization name The Wistar Institute
Department Gene expression and regulation
Street address 3601 Spruce street
City Philadelphia
State/province PA
ZIP/Postal code 19104
Country USA
 
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (37)
GSM2803052 ARID1A_REP1
GSM2803053 ARID1A_REP2
GSM2803054 ATACSEQ_CTRL_REP1
Relations
BioProject PRJNA413026
SRA SRP119318

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE104545_RAW.tar 9.6 Gb (http)(custom) TAR (of BW, TXT)
SRA Run SelectorHelp
Processed data provided as supplementary file
Raw data are available in SRA

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