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Series GSE103788 Query DataSets for GSE103788
Status Public on Sep 11, 2019
Title Elimination of liver cancer cells by YAP activated hepatocytes
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Liver tumors activate a regeneration-like genetic program in surrounding liver tissue akin to the regeneration program activated by toxic liver injury. Using genetically engineered mouse models we show that this program is regulated by the Hippo pathway. Our results identify a novel mechanism of non-autonomous tumor suppression where activation of a regeneration-like program in normal cells around liver tumors caused tumor cell death and tumor regression. Strikingly, deleting YAP specifically in peritumoral hepatocytes resulted in hepatocyte death and enhanced tumor growth, while hyperactivating YAP in peritumoral hepatocytes caused the elimination of tumor cells and tumor regression.
Overall design RNA-seq on purified hepatocytes from untreated control livers, livers with tumors and after toxic injury (24 and 48h after TAA).
Contributor(s) Halder G, Moya I, Jacobs J
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Submission date Sep 13, 2017
Last update date Sep 11, 2019
Contact name Jelle Jacobs
Organization name KULeuven
Department Human Genetics
Lab Lab of Computational Biology
Street address Herestraat 49
City Leuven
ZIP/Postal code 3000
Country Belgium
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (12)
GSM2781912 L_TAA_24_r1
GSM2781913 L_TAA_24_r2
GSM2781914 L_TAA_48_r1
BioProject PRJNA407049
SRA SRP117567

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Supplementary file Size Download File type/resource
GSE103788_filtered_RPM_genes.tsv.gz 1.3 Mb (ftp)(http) TSV
GSE103788_raw_counts_genes.tsv.gz 641.9 Kb (ftp)(http) TSV
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Processed data are available on Series record

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