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Status |
Public on Oct 01, 2018 |
Title |
The Estrogen Receptor α (ERα) has stage- and cell type-specific roles in the mammary epithelium with distinct requirements for activation function-1 and -2 |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
|
Summary |
We provide evidence that luminal responder cells express low level ERα required for cell expansion during ductal growth but growth inhibitor during pregnancy.
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Overall design |
Intraductally engrafted WT.GFP+ or ERα-/-.GFP+ cells from contralateral glands of the pregnant NSG hosts by FACS sorting for GFP and analysed global gene expression of 3 independent samples by RNA sequencing.
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Contributor(s) |
Cagnet S, Ataca D, Sflomos G, Schuepbach-Mallepell S, Aouad P, Hugues H, Krust A, Ayyannan A, Scabia V, Brisken C |
Citation(s) |
30413705 |
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Submission date |
Sep 08, 2017 |
Last update date |
May 15, 2019 |
Contact name |
George A Sflomos |
E-mail(s) |
georgios.sflomos@epfl.ch
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Phone |
0041(0)216930784
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Organization name |
EPFL
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Department |
ISREC
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Lab |
BRISKEN
|
Street address |
SV 2815, Batiment SV, Station 19
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City |
Lausanne |
ZIP/Postal code |
1024 |
Country |
Switzerland |
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Platforms (1) |
GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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Samples (6)
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Relations |
BioProject |
PRJNA403857 |
SRA |
SRP117180 |