|
| Status |
Public on Oct 01, 2018 |
| Title |
The Estrogen Receptor α (ERα) has stage- and cell type-specific roles in the mammary epithelium with distinct requirements for activation function-1 and -2 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We provide evidence that luminal responder cells express low level ERα required for cell expansion during ductal growth but growth inhibitor during pregnancy.
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| |
|
| Overall design |
Intraductally engrafted WT.GFP+ or ERα-/-.GFP+ cells from contralateral glands of the pregnant NSG hosts by FACS sorting for GFP and analysed global gene expression of 3 independent samples by RNA sequencing.
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| |
|
| Contributor(s) |
Cagnet S, Ataca D, Sflomos G, Schuepbach-Mallepell S, Aouad P, Hugues H, Krust A, Ayyannan A, Scabia V, Brisken C |
| Citation(s) |
30413705 |
| |
| Submission date |
Sep 08, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
George A Sflomos |
| E-mail(s) |
georgios.sflomos@epfl.ch
|
| Phone |
0041(0)216930784
|
| Organization name |
EPFL
|
| Department |
ISREC
|
| Lab |
BRISKEN
|
| Street address |
SV 2815, Batiment SV, Station 19
|
| City |
Lausanne |
| ZIP/Postal code |
1024 |
| Country |
Switzerland |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (6)
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|
| Relations |
| BioProject |
PRJNA403857 |
| SRA |
SRP117180 |
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