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| Status |
Public on Oct 17, 2017 |
| Title |
The Circadian Clock Gene Bmal1 Controls Thyroid Hormone-Mediated Spectral Identity and Cone Photoreceptor Function |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Here we reveal a novel role for the circadian clock gene Bmal1 and Period2 in regulating the spatial organization of the cone opsins. Deletion of Bmal1 and Per2 have opposing effects on S-opsin expression and patterning of the cone photoreceptors is disrupted in cone specific knockouts of these genes. Using ChIP analysis we show that BMAL1 directly binds to the promoter region of the thyroid activating enzyme type II deiodinase (Dio2).
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| |
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| Overall design |
3 WT vs 3 Bmal1 CKO mice were compared
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| |
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| Contributor(s) |
Sawant O, Rao S |
| Citation missing |
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| |
| Submission date |
Sep 05, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Ernest R Chan |
| E-mail(s) |
erc6@case.edu
|
| Organization name |
CWRU
|
| Department |
PQHS
|
| Street address |
10900 Euclid Ave, Robbins E211
|
| City |
Cleveland |
| State/province |
OH |
| ZIP/Postal code |
44106 |
| Country |
USA |
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| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA401776 |
| SRA |
SRP116906 |
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