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Series GSE103359 Query DataSets for GSE103359
Status Public on Nov 05, 2018
Title Epigenetic correction of defective plasticity in a tauopathy mouse model with an acetyltransferase activator [RNA-Seq]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary In the adult brain, histone acetylation is associated with activity-regulated transcriptional changes that are required for synaptic plasticity and memory. These processes are dismantled in neurodegenerative diseases. Here, we demonstrate that synaptic plasticity and memory deficiencies can be restored in a mouse model of tauopathy following treatment with CSP-TTK21, a small molecule activator of CBP/p300 histone acetyltransferases (HAT). CSP-TTK21 normalized the H2B acetylation levels in many genes, including a series of super-enhancer –regulated genes, associated with plasticity and neuronal function in resting tauopathic mice. CSP-TTK21 re-established part of the learning-induced hippocampal transcriptome, including the induction of immediate early genes and memory-related genes, and the down-regulation of neuronal identity genes that bear super-enhancers. This study is the first to provide in vivo proof-of-concept evidence that direct activation of CBP/p300 HAT efficiently and selectively reverses epigenetic, transcriptional, synaptic plasticity, and behavioral deficits associated to Alzheimer’s disease lesions in mice.
Overall design RNA profiles by deep sequencing using Illumina HiSeq 2500 obtained from Dorsal Hippocampus of WT and THY-Tau22 mice, not treated or treated with either Saline (S), CSP (C) ors CSP-TTK21 (T), in basal (resting, no training) or behavior (spatial training) conditions, as noted.
Contributor(s) Boutillier A
Citation(s) 30275019
Submission date Aug 31, 2017
Last update date Mar 11, 2019
Contact name Anne-Laurence Boutillier
Organization name UMR7364
Department LNCA
Street address 12 rue Goethe
City Strasbourg
ZIP/Postal code 67000
Country France
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (14)
GSM2769422 WT_rep1
GSM2769423 WT_rep2
GSM2769424 WT_rep3
This SubSeries is part of SuperSeries:
GSE103360 Epigenetic correction of defective plasticity in a tauopathy mouse model with an acetyltransferase activator
BioProject PRJNA401661
SRA SRP131333

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE103359_S14061_mm9_genesdiff_groups.txt.gz 1.1 Mb (ftp)(http) TXT
GSE103359_S15010_genesdiff_HS179_HS190.txt.gz 1.7 Mb (ftp)(http) TXT
Raw data provided as supplementary file
Processed data is available on Series record

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