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Series GSE103358 Query DataSets for GSE103358
Status Public on Nov 05, 2018
Title Epigenetic correction of defective plasticity in a tauopathy mouse model with an acetyltransferase activator [ChIP-Seq]
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary In the adult brain, histone acetylation is associated with activity-regulated transcriptional changes that are required for synaptic plasticity and memory. These processes are dismantled in neurodegenerative diseases. Here, we demonstrate that synaptic plasticity and memory deficiencies can be restored in a mouse model of tauopathy following treatment with CSP-TTK21, a small molecule activator of CBP/p300 histone acetyltransferases (HAT). CSP-TTK21 normalized the H2B acetylation levels in many genes, including a series of super-enhancer –regulated genes, associated with plasticity and neuronal function in resting tauopathic mice. CSP-TTK21 re-established part of the learning-induced hippocampal transcriptome, including the induction of immediate early genes and memory-related genes, and the down-regulation of neuronal identity genes that bear super-enhancers. This study is the first to provide in vivo proof-of-concept evidence that direct activation of CBP/p300 HAT efficiently and selectively reverses epigenetic, transcriptional, synaptic plasticity, and behavioral deficits associated to Alzheimer’s disease lesions in mice.
 
Overall design Examination of H2Bac and H3k27ac in the dorsal hippocampus by deep sequencing
 
Contributor(s) Boutillier A
Citation(s) 30275019
Submission date Aug 31, 2017
Last update date Mar 21, 2019
Contact name Anne-Laurence Boutillier
E-mail laurette@unistra.fr
Organization name UMR7364
Department LNCA
Street address 12 rue Goethe
City Strasbourg
ZIP/Postal code 67000
Country France
 
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (15)
GSM2769407 dHIP_WT_Input_rep1
GSM2769408 dHIP_TAU CSP_Input_rep1
GSM2769409 dHIP_TAU CSPTTK21_Input_rep1
This SubSeries is part of SuperSeries:
GSE103360 Epigenetic correction of defective plasticity in a tauopathy mouse model with an acetyltransferase activator
Relations
BioProject PRJNA401662
SRA SRP131332

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE103358_RAW.tar 2.9 Gb (http)(custom) TAR (of WIG)
Raw data provided as supplementary file
Processed data provided as supplementary file

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