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| Status |
Public on Aug 10, 2020 |
| Title |
Fatty liver disease caused by high alcohol-producing Klebsiella pneumoniae |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
To further explore the overall development and progression of hepatic steatosis induced by HiAlc Kpn, we examined liver transcriptional profiles derived HiAlc Kpn-fed, pair-fed, or ethanol-fed mice for the 4th, 6th and 8th week post gavage. The liver gene expressions in mice both with HiAlc Kpn-fed and ethanol-fed have been showed large diversities to pair-fed mice. These results clearly illustrated a process of chronic liver injury, which is consistent with previous “two-hits” insulin hypothesis, and suggested that endogenous ethanol produced by HiAlc Kpn play important roles in the steatohepatitis, as well as alcohol intake.
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| Overall design |
Kpn-fed, pair-fed (negative control), or ethanol-fed induced gene expression in mice was measured at 4th, 6th and 8th week post gavage.
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| Contributor(s) |
Yuan J, Lu J, Cheng W |
| Citation(s) |
31543403, 34632939 |
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| Submission date |
Aug 10, 2017 |
| Last update date |
Oct 19, 2021 |
| Contact name |
Jing Lu |
| E-mail(s) |
13716207513@163.com
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| Organization name |
Academy of Military Medical Sciences
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| Street address |
Beijing, Fengtai District,100071, China
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| City |
Beijing |
| ZIP/Postal code |
100071 |
| Country |
China |
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| Platforms (1) |
| GPL10787 |
Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Probe Name version) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA397861 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE102489_RAW.tar |
142.7 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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