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| Status |
Public on May 22, 2019 |
| Title |
KDM4B epigenetically protects against obesity and metabolic dysfunction [gene expression] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
KDM4B (lysine demethylase 4B) in adipose tissues plays a critical role in energy balance, oxidation, lipolysis and thermogenesis. Loss of KDM4B in mice resulted in obesity associated with reduced energy expenditure and impaired adaptive thermogenesis.
Mechanistically, we determined that KDM4B directly controls the expression of multiple metabolic genes.
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| Overall design |
To explore the molecular mechanisms of Kdm4b deficiency-induced obesity, we performed a microarray analysis on the Epi, SubQ and BAT of 2-month-old WT and whole body Kdm4b KO mice
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| Contributor(s) |
Wang C, Cheng Y |
| Citation(s) |
29844188 |
| |
| Submission date |
Aug 04, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Cunyu Wang |
| E-mail(s) |
cwang@dentistry.ucla.edu
|
| Phone |
3108256317
|
| Organization name |
UCLA
|
| Department |
School of Dentistry
|
| Lab |
CHS 56-200
|
| Street address |
10833 Le Conte Ave
|
| City |
Los Angeles |
| State/province |
CA |
| ZIP/Postal code |
90095 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE102290 |
KDM4B epigenetically protects against obesity and metabolic dysfunction |
|
| Relations |
| BioProject |
PRJNA397227 |
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