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Series GSE102244 Query DataSets for GSE102244
Status Public on Aug 23, 2017
Title Zika Virus Has Oncolytic Activity against Glioblastoma Stem Cells
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We explored the utility of oncolytic virus therapy against glioblastoma with Zika virus (ZIKV), a flavivirus that induces cell death and differentiation of neural precursor cells in the developing fetus. ZIKV preferentially infected and killed glioblastoma stem cells (GSCs) relative to differentiated tumor progeny or normal neuronal cells. The effects against GSCs were not a general property of neurotropic flaviviruses, as West Nile Virus (WNV) indiscriminately killed both tumor and normal neural cells. ZIKV potently depleted patient-derived GSCs grown in culture and in organoids. Moreover, mice with glioblastoma survived substantially longer and at greater rates when the tumor was inoculated with a murine adapted strain of ZIKV. Our results suggest that ZIKV is an oncolytic virus that can preferentially target GSCs, and thus, genetically modified strains that further optimize safety could have therapeutic efficacy for adult glioblastoma patients.
Overall design RNA-seq of glioblastoma stem cells and non-stem tumor cells. These samples have not been infected with Zika virus.
Contributor(s) Zhu Z, Rich JN, Chheda M
Citation(s) 28874392
Submission date Aug 03, 2017
Last update date May 15, 2019
Contact name Briana Prager
Organization name Cleveland Clinic
Street address 9500 Euclid Ave.
City Cleveland
State/province OH
ZIP/Postal code 44195
Country USA
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (6)
GSM2731720 3691 GSC
GSM2731721 3691 NSTC
GSM2731722 3565 GSC
BioProject PRJNA397077
SRA SRP114793

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Supplementary file Size Download File type/resource
GSE102244_zheZhu2017_cufflinks.txt.gz 1.3 Mb (ftp)(http) TXT
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