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| Status |
Public on Dec 04, 2018 |
| Title |
Differential expression of long non‑coding RNA and mRNA in children with Henoch‑Schönlein purpura nephritis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Non-coding RNA profiling by high throughput sequencing
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| Summary |
Long non‑coding RNAs (lncRNAs) serve an essential role in regulating immunological functions. However, their impact on Henoch‑Schönlein purpura nephritis (HSPN), has remained elusive.
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| Overall design |
The present study determined the expression of lncRNAs and mRNAs in the peripheral blood of 6 children with HSPN and recruited 4 healthy children for comparative study. High‑throughput sequencing revealed outstanding differences in lncRNA and mRNA expression, which were verified through reverse transcription‑quantitative polymerase chain reaction. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were used to investigate the associated biological functions and possible mechanisms of lncRNAs and mRNAs in HSPN.
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| Web link |
https://doi.org/10.3892/etm.2018.7038
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| |
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| Contributor(s) |
Pang S, Zhang J |
| Citation(s) |
30651843 |
| |
| Submission date |
Aug 01, 2017 |
| Last update date |
Jan 25, 2023 |
| Contact name |
shuang pang |
| E-mail(s) |
meetpang@sandau.edu.cn
|
| Phone |
+8618102459998
|
| Organization name |
Liaoning University of Traditional Chinese Medicine
|
| Street address |
No.79 Chong Shan Dong Lu Street
|
| City |
Shenyang |
| State/province |
China |
| ZIP/Postal code |
110032 |
| Country |
China |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA396725 |
| SRA |
SRP114505 |
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