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Series GSE101882 Query DataSets for GSE101882
Status Public on Jul 27, 2017
Title Gene expression of young, middle-aged and old Drosophila melanogaster exposed to different levels of larval and adult diet
Organism Drosophila melanogaster
Experiment type Expression profiling by array
Summary Many studies have addressed the effects of adult diet on gene expression in Drosophila melanogaster, however, little is known about how developmental diet influences adult gene expression, and how this interacts with adult dietary conditions.
We found that developmental and adult diet exert largely independent effects on gene expression, with the effect of adult diet being considerably larger.We did find effects of developmental diet on the transcriptome that persist into middle and old-age. Most of the genes affected show no correlation with the observed phenotypic effects of larval diet on lifespan, however, in each sex we identified a cluster of ribosome, transcription, and translation-related genes whose expression was altered across the lifespan and negatively correlated with lifespan.
Overall design We raised flies as larvae on three different diets and switched them across these same diets as adults, using a fully factorial design (3 larval * 3 adult diets = 9 treatments in total). We measured gene expression in both sexes at 1 day post-eclosion, middle-age (10% cohort mortality) and old-age (90% cohort mortality).
Contributor(s) May CM, Zwaan BJ
Citation(s) 28830340
Submission date Jul 26, 2017
Last update date May 04, 2018
Contact name Christina May
Organization name Wageningen University
Street address Droevendaalsesteeg 1
City Wageningen
State/province Gelderland
ZIP/Postal code 6708 PB
Country Netherlands
Platforms (1)
GPL1322 [Drosophila_2] Affymetrix Drosophila Genome 2.0 Array
Samples (216)
GSM2717735 Adult 10% cohort mortality 1SY/1SY F1
GSM2717736 Adult 10% cohort mortality 1SY/1SY F2
GSM2717737 Adult 10% cohort mortality 1SY/1SY F3
BioProject PRJNA395848

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Supplementary file Size Download File type/resource
GSE101882_RAW.tar 451.0 Mb (http)(custom) TAR (of CEL)
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Raw data provided as supplementary file
Processed data included within Sample table

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