|
| Status |
Public on Feb 01, 2018 |
| Title |
Functional and genomic characterization of a xenograft model system for the study of metastasis in triple-negative breast cancer. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To define the molecular regulators of metastasis of triple-negative breast cancer, we conducted a rigorous characterization of four isogenic populations of MDA-MB-231 human triple-negative breast cancer cells that display a range of intrinsic spontaneous metastatic capacities in immuno-deficient mice, from non-metastatic to highly metastatic to lung, liver, spleen and spine. PAT-Seq gene expression profiling of primary tumor cells identified the fibroblast growth factor homologous factor, FGF13, as a candidate metastatic virulence gene highly upregulated in aggressively metastatic MDA-MB-231HM tumors.
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| |
|
| Overall design |
Gene expression analysis from PAT-Seq of 4 increasingly metastatic breast cancer xenograft tumours
|
| |
|
| Contributor(s) |
Pattison AD, Harrison PF, Powell DR, Beilharz TH |
| Citation(s) |
29720474 |
| |
| Submission date |
Jul 21, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Andrew Pattison |
| E-mail(s) |
andrew.pattison@monash.edu
|
| Organization name |
Monash University
|
| Street address |
Wellington Rd
|
| City |
Melbourne |
| State/province |
Vic |
| ZIP/Postal code |
3800 |
| Country |
Australia |
| |
|
| Platforms (1) |
| GPL18460 |
Illumina HiSeq 1500 (Homo sapiens) |
|
| Samples (20)
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| This SubSeries is part of SuperSeries: |
| GSE111706 |
Metastasis in triple-negative breast cancer |
|
| Relations |
| BioProject |
PRJNA395339 |
| SRA |
SRP113305 |
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