|
| Status |
Public on Aug 02, 2017 |
| Title |
p53 binding during the DNA double-strand break response |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We used ChIP-seq to assess where p53 binds in the human genome and how that binding changes during the DNA double-strand break response. In particular, we considered the 1-Mb-wide window centered on the MYC locus. Contrary to previous reports, we found no evidence of p53 binding at the MYC promoter. Rather, we identified three locations downstream of MYC at which p53 was bound; binding at each of these regions increased during the DNA double-strand break response.
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| |
|
| Overall design |
Examination of p53 binding in cells with/without DNA double-strand breaks.
|
| |
|
| Contributor(s) |
Porter JR, Baranello L, Batchelor E |
| Citation(s) |
28867293 |
| |
| Submission date |
Jul 21, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Eric Batchelor |
| E-mail(s) |
batchelore@mail.nih.gov
|
| Organization name |
National Institutes of Health
|
| Department |
LP/CCR/NCI
|
| Street address |
10 Center Dr
|
| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (6)
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| Relations |
| BioProject |
PRJNA395320 |
| SRA |
SRP113290 |
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