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Series GSE101295 Query DataSets for GSE101295
Status Public on Dec 22, 2017
Title c-MYC drives a subset of high-risk pediatric neuroblastomas and is activated through mechanisms including enhancer hijacking and focal enhancer amplification (ChIP-Seq)
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Childhood neuroblastoma is known for MYCN gene amplification, and here we show that in a separate subset of cases MYC-itself is activated due to enhancer hijacking from chromosomal translocations or duplications, thus defining a unique subset of high-risk disease.
 
Overall design ChIP-Seq for H3K27ac and CTCF in high MYC expressing neuroblastoma cell types
 
Contributor(s) Zimmerman MW, Liu Y, He S, Durbin AD, Abraham BJ, Weichert-Leahey N, Zhu S, Khan A, Zhang X, Young RA, Zhang J, Look AT
Citation(s) 29284669
Submission date Jul 12, 2017
Last update date May 15, 2019
Contact name Richard A Young
E-mail(s) young_computation@wi.mit.edu
Phone 617-258-5219
Organization name Whitehead Institute for Biomedical Research
Lab Young Lab
Street address 9 Cambridge Center
City Cambridge
State/province MA
ZIP/Postal code 02142
Country USA
 
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (12)
GSM2700776 SKNAS H3K27ac [Lab: Look]
GSM2700777 SKNAS input [Lab: Look]
GSM2700778 NB69 H3K27ac [Lab: Look]
This SubSeries is part of SuperSeries:
GSE101297 c-MYC drives a subset of high-risk pediatric neuroblastomas and is activated through mechanisms including enhancer hijacking and focal enhancer amplification
Relations
BioProject PRJNA398586
SRA SRP125903

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE101295_RAW.tar 932.3 Mb (http)(custom) TAR (of WIG)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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