|
| Status |
Public on Dec 22, 2017 |
| Title |
c-MYC drives a subset of high-risk pediatric neuroblastomas and is activated through mechanisms including enhancer hijacking and focal enhancer amplification (ChIP-Seq) |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Childhood neuroblastoma is known for MYCN gene amplification, and here we show that in a separate subset of cases MYC-itself is activated due to enhancer hijacking from chromosomal translocations or duplications, thus defining a unique subset of high-risk disease.
|
| |
|
| Overall design |
ChIP-Seq for H3K27ac and CTCF in high MYC expressing neuroblastoma cell types
|
| |
|
| Contributor(s) |
Zimmerman MW, Liu Y, He S, Durbin AD, Abraham BJ, Weichert-Leahey N, Zhu S, Khan A, Zhang X, Young RA, Zhang J, Look AT |
| Citation(s) |
29284669 |
| Submission date |
Jul 12, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Richard A Young |
| E-mail(s) |
young_computation@wi.mit.edu
|
| Phone |
617-258-5219
|
| Organization name |
Whitehead Institute for Biomedical Research
|
| Lab |
Young Lab
|
| Street address |
9 Cambridge Center
|
| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02142 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (12)
|
|
| This SubSeries is part of SuperSeries: |
| GSE101297 |
c-MYC drives a subset of high-risk pediatric neuroblastomas and is activated through mechanisms including enhancer hijacking and focal enhancer amplification |
|
| Relations |
| BioProject |
PRJNA398586 |
| SRA |
SRP125903 |
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