|
| Status |
Public on Feb 11, 2009 |
| Title |
Time course of MEK inhibition |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
This study used microarray expression analysis to identify global changes in transcript alteration in response to MEK inhibition. Genes under ERK control were identified in a representative V600E BRAF cell line as a function of time following exposure to a small molecule inhibitor of MEK.
Keywords: Time course
|
| |
|
| Overall design |
SkMel-28 cells growing in culture were treated with the MEK inhibitor PD0325901 for 2, 8, or 24 hours. Changes in RNA compared to reference (time =0) were measured using microarray analysis.
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| |
|
| Contributor(s) |
Pratilas CA, Taylor BS |
| Citation(s) |
19251651 |
| |
| Submission date |
Jan 07, 2008 |
| Last update date |
Dec 06, 2018 |
| Contact name |
Christine Anne Pratilas |
| E-mail(s) |
pratilac@mskcc.org
|
| Phone |
646 888 3121
|
| Organization name |
Memorial Sloan-Kettering Cancer Center
|
| Department |
Molecular Pharmacology
|
| Lab |
Molecular Oncogenesis
|
| Street address |
1275 York Avenue
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10065 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
|
| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE10086 |
Expression profiling of V600E BRAF and RTK-activated cells upon MEK inhibition |
|
| Relations |
| BioProject |
PRJNA108973 |
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