|
| Status |
Public on Feb 11, 2009 |
| Title |
Paired MEK inhibited and control |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
This study used microarray expression analysis to identify global changes in transcript alteration in response to MEK inhibition. Genes under ERK control were identified in a panel of V600E BRAF and RTK-activated tumor cells and xenografts, using short-term inhibition of ERK activity using the MEK inhibitor PD0325901 (Pfizer).
Keywords: paired treatment and control
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| Overall design |
Cell lines growing in culture (n=12) and murine xenografts (n=2) were treated with the MEK inhibitor PD0325901 or vehicle alone as control. Paired analysis of MEK inhibited to control samples was performed for two groups of tumor cells, V600E BRAF and RTK.
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| |
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| Contributor(s) |
Pratilas CA, Taylor BS |
| Citation(s) |
19251651 |
| |
| Submission date |
Jan 07, 2008 |
| Last update date |
Dec 06, 2018 |
| Contact name |
Christine Anne Pratilas |
| E-mail(s) |
pratilac@mskcc.org
|
| Phone |
646 888 3121
|
| Organization name |
Memorial Sloan-Kettering Cancer Center
|
| Department |
Molecular Pharmacology
|
| Lab |
Molecular Oncogenesis
|
| Street address |
1275 York Avenue
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10065 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
|
| Samples (32)
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| This SubSeries is part of SuperSeries: |
| GSE10086 |
Expression profiling of V600E BRAF and RTK-activated cells upon MEK inhibition |
|
| Relations |
| BioProject |
PRJNA108971 |
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