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Status |
Public on Jul 23, 2018 |
Title |
SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia |
Organism |
Homo sapiens |
Experiment type |
Genome variation profiling by SNP array SNP genotyping by SNP array
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Summary |
We identified novel recurrent genetic lesions in T-PLL affecting genes involved in JAK/STAT signaling (PTPRC), epigenetic regulation (PRDM2), or DNA damage repair (SAMHD1, PARP10, HERC1, HERC2). Mutations of the tumor suppressor gene SAMHD1 causing amino-acid exchanges or protein truncations as well as copy number variations in SAMHD1 were seen in 20% of cases.
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Overall design |
Copy number variation analysis (Affymetrix SNP 6.0 and CytoHD Arrays) of 14 T-PLL patients.
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Contributor(s) |
Klein-Hitpass L, Johansson P |
Citation(s) |
29352181 |
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Submission date |
Jul 05, 2017 |
Last update date |
Jul 25, 2021 |
Contact name |
Ludger Klein-Hitpass |
E-mail(s) |
ludger.klein-hitpass@uni-essen.de
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Phone |
+49 201 723 85552
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Organization name |
Institut fuer Zellbiologie
|
Department |
Universitaetsklinikum
|
Lab |
BioChip Lab
|
Street address |
Virchowstr. 173
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City |
Essen |
ZIP/Postal code |
D-45122 |
Country |
Germany |
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Platforms (2) |
GPL6801 |
[GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array |
GPL16131 |
[CytoScanHD_Array] Affymetrix CytoScan HD Array |
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Samples (14)
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Relations |
BioProject |
PRJNA393223 |