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| Status |
Public on Jul 30, 2019 |
| Title |
Expression patterns of key miRNAs in end-stage ADPKD kidneys |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
|
| Summary |
To investigate altered expression patterns of key miRNAs in end-stage ADPKD kidneys, a miRNA microarray analysis was performed using non-ADPKD and ADPKD kidney tissue samples. As a result, total 19 miRNAs were significantly changed in the ADPKD samples compared with non-ADPKD samples. Among these miRNAs, the expression level of the miR-192 family including miR-192 and miR-194 were significantly downregulated in ADPKD.
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| Overall design |
Renal cyst tissue samples were obtained from patients with ADPKD undergoing nephrectomy. As a control, non-ADPKD renal tissue samples were obtained from patients undergoing surgery for clear cell renal cell carcinoma, where malignant cell infiltration was excluded by histology.
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| |
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| Contributor(s) |
Park J, Woo Y, Lee S, Kim D |
| Citation(s) |
30332302 |
| |
| Submission date |
Jul 05, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Sumin Oh |
| E-mail(s) |
kstori3924@gmail.com
|
| Phone |
82-10-7203-2307
|
| Organization name |
Sookmyung Women's University
|
| Department |
Department of Biological Science
|
| Lab |
LBG
|
| Street address |
Cheongpa-ro 47-gil 100, Yongsan-gu
|
| City |
Seoul |
| ZIP/Postal code |
04310 |
| Country |
South Korea |
| |
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| Platforms (1) |
| GPL18743 |
Agilent-021827 Human miRNA Microarray [miRNA_107_Sep09] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA393165 |
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