|
| Status |
Public on Jun 30, 2018 |
| Title |
KMT2C medaites the estrogen dependence of breast cancer through regulation of ERα enhancer function |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
KMT2C is a key regulator of ERα activity whose loss allows for hormone independent proliferation in MCF7 cells
|
| |
|
| Overall design |
Examination of RNA seq and ChIP seq in cells with KMT2C knockdown as well as cells with KMT2C knockdown that have gorwn out in hormone-deprived media
|
| |
|
| Contributor(s) |
Gala K, Chandarlapaty S |
| Citation(s) |
29755131 |
| |
| Submission date |
Jun 21, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Kinisha Gala |
| E-mail(s) |
galak@mskcc.org
|
| Organization name |
Memorial Sloan Kettering Cancer Center
|
| Street address |
417 E. 68th Street
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10065 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (47)
|
|
| Relations |
| BioProject |
PRJNA391343 |
| SRA |
SRP110043 |
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