NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE100074 Query DataSets for GSE100074
Status Public on Jan 12, 2018
Title Discovery of naturally occurring ESR1 mutations during acquisition of resistance to endocrine therapy in widely used estrogen receptor positive breast cancer cell lines [ChIP-Seq]
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary We report the first discovery of naturally occurring ESR1Y537C and ESR1Y537S mutations in MCF7 and MCF7 ESR1-positive cell-lines after acquisition of resistance to long-term-estrogen-deprivation (LTED) and subsequent resistance to fulvestrant (ICIR).
 
Overall design Examination of ER binding in breast cancer cell lines with and without ESR1 mutations
 
Contributor(s) Schuster E, Martin L
Citation(s) 29192207
Submission date Jun 15, 2017
Last update date May 15, 2019
Contact name Eugene Schuster
E-mail(s) gschuster@icr.ac.uk
Phone +442088082619
Organization name Institute of Cancer Research
Department Breast Cancer Research
Lab Endocrinology
Street address 123 Old Brompton Road
City London
ZIP/Postal code SW7 3RP
Country United Kingdom
 
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (12)
GSM2670862 MCF7_WT
GSM2670863 MCF7_LTED_WT
GSM2670864 MCF7_LTED_MUT
This SubSeries is part of SuperSeries:
GSE100076 Discovery of naturally occurring ESR1 mutations during acquisition of resistance to endocrine therapy in widely used estrogen receptor positive breast cancer cell lines
Relations
BioProject PRJNA390635
SRA SRP109285

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE100074_RAW.tar 10.5 Mb (http)(custom) TAR (of XLS)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap