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| Status |
Public on Jul 16, 2022 |
| Title |
Assessing the role of TPL2 in TauP301S mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
ScRNAseq analysis shows
•TPL2 KD (kinase dead) reduced TauP301S dependent IEG and MHCII activation states in microglia
•TPL2 KD reduced peripheral immune cell infiltration in TauP301S mouse brain
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| Overall design |
Single cell suspensions of mouse hippocampi were obtained by FACS from ~ 9-month-old TPL2 KD mice crossed with TauP301S mice and littermate control mice.
Samples analyzed:
1. Tpl2 wt/wt, Tau P301S -/-, n = 3
2. Tpl2 kd/kd, Tau P301S -/-, n = 3
3. Tpl2 wt/wt, Tau P301S +/-, n = 6
4. Tpl2 kd/kd Tau P301S +/-, n = 6
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| |
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| Contributor(s) |
Wang Y, Hanson J, Friedman B, Rezzonico M, Mohamed A, Modrusan Z |
| Citation(s) |
37118504 |
| |
| Submission date |
Jul 13, 2021 |
| Last update date |
Aug 02, 2023 |
| Contact name |
Alyaa M Mohamed |
| E-mail(s) |
alyaa.mohamed@roche.com
|
| Phone |
4373391720
|
| Organization name |
Hoffman La Roche
|
| Street address |
7070 Mississauga Road Mississauga, ON L5N 5M8 Canada
|
| City |
Mississauga |
| State/province |
Ontario |
| ZIP/Postal code |
L5N 5M8 |
| Country |
Canada |
| |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA746341 |
| SRA |
SRP328209 |
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