Selective inhibition of matrix mechanosensing in stromal cells attenuates cardiovascular fibrosis

Scalable single-cell pooled CRISPR screens with conventional knockout vector libraries

Heterogeneous Cardiac- and Neural Crest-Derived Aortic Smooth Muscle Cells have Similar Transcriptional Changes after TGFβ Signaling Disruption

POISONING OF HEALTHY HEMATOPOIESIS IS AN UNANTICIPATED MECHANISM DRIVING CLONAL DOMINANCE IN VEXAS SYNDROME [scRNA-seq]

Intrapulmonary metastases of non-small cell lung cancer promoted by a hotspot gain-of-function mutation in KMT2C

HoxBlinc lncRNA reprograms CTCF-independent TADs to drive leukemic transcription and HSC dysregulation in NUP98 fusion transformed leukemia

G-Quadruplex DNA Suppresses Transcriptional Pause Release During DNA Replication

Inhaled Xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy

Antiandrogen treatment endows ZMYDN8 dependent epigenetic reprogramming to orchestrate neuroendocrine tumor transdifferentiation

Regulation of sarcomere formation and function in the healthy heart requires a titin intronic enhancer.

Evolution of myeloid-mediated immunotherapy resistance in prostate cancer

Latent Epigenetic Programs in Müller Glia Contribute to Stress, Injury, and Disease Response in the Retina [scRNA-seq]

IgE plasma cells differentially regulate antibody secretion, ER stress and tissue-specific longevity relative to other isotypes

Dual nuclease single-cell lineage tracing by Cas9 and Cas12a

Exosomal miR-302b rejuvenates aging mice by reversing cell cycle arrest

CPSF6-RARγ Interacts with HDAC3 to Promote Myeloid Transformation

Human single cell RNA-sequencing reveals a targetable CD8+ exhausted T cell population that maintains murine low-grade glioma growth

Characterization and bioinformatic filtering of ambient gRNAs in single-cell CRISPR screens using CLEANSER [scRNA-seq]

Decoding the immune checkpoint signatures in human atherosclerosis: implications of type 2 diabetes and lipid-lowering intervention

Unveiling Cancer-Related Metaplastic Cells in Both Helicobacter pylori Infection and Autoimmune Gastritis