DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation

Nuclear receptor-SINE B1 network modulates expanded pluripotency in blastoids and blastocysts.

FoxA1/2-dependent epigenomic reprogramming drives lineage switching in lung adenocarcinoma

Cancer-associated DNA Hypermethylation of Polycomb Targets Requires DNMT3A Dual Recognition of histone H2AK119 Ubiquitination and the Nucleosome Acidic Patch

Epigenetic profiling in adult brain after prenatal BPA exposure

Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity

AMAR-seq: automated multimodal sequencing of DNA methylation, chromatin accessibility, and RNA expression with single-cell resolution

Astrocyte Reactivity and Cognitive Decline Follow Chronic Heterochromatin Loss in Neurons

Durable and efficient gene silencing in vivo by hit-and-run epigenome editing

Astrocyte-produced HB-EGF limits autoimmune CNS pathology

Gestational diabetes in mice induces hematopoietic memory that impacts the long-term health of the offspring

Transcriptional and epigenetic reprogramming mediated by chronic IL1β exposure drives self-renewal ability and myeloid priming in TET2 deficient stem and progenitor cells

A maternal-effect Padi6 variant causes nuclear and cytoplasmic abnormalities in oocytes as well 2 as failure of epigenetic reprogramming and zygotic genome activation in embryos

An engineered Sox17 induces somatic to neural stem cell fate transition independently from pluripotency reprogramming

Joint single-cell profiling resolves 5mC and 5hmC and reveals their distinct gene regulatory effects

DNA methylation and gene expression changes in mice induced by parabiosis and recovery

The chemical reprogramming of unipotent adult germ cells towards authentic pluripotency and de novo establishment of imprinting

Single-cell triple-omics uncovers DNA methylation as key feature of stemness in the healthy and ischemic adult brain

The major urinary protein gene cluster knockout mouse as a novel model for translational metabolism research

TET proteins regulate T cell and iNKT cell lineage specification in a TET2 catalytic dependent manner.