Inhibition of SWI/SNF broadly disrupts enhancers and reveals remodeler redundancy at promoters

Single-cell parallel analysis of DNA damage and transcriptome reveals selective genome vulnerability

Rational design of a SOCS1-edited tumor infiltrating lymphocyte therapy for solid tumors using CRISPR/Cas9 screens

Study of 5mC-DNA, m6A-RNA and RNA-expression in HeLa, ES and EB

Joint epigenome profiling reveals cell-type-specific gene regulatory programs in human cortical organoids

Enhancer grammar of liver cell types and hepatocyte zonation states

Genome editing by dual nucleases records deep lineage hierarchy with high fidelity.

Dual nuclease single-cell lineage tracing by Cas9 and Cas12a

Transcriptomics of skin reveal potential molecular mechanisms of psoriasis

A single cell atlas of human glioma under therapy

DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation

The histone acetyltransferase MOZ is a molecular dependency and therapeutic target in NUP98-rearranged acute myeloid leukemia [WGS, ATACseq, CUT&RUN, scRNAseq]

Decoding the immune checkpoint signatures in human atherosclerosis: implications of type 2 diabetes and lipid-lowering intervention

Single-nucleus multiomic mapping of m6A methylome and transcriptome in native populations of cells with sn-m6A-CT [scRNA-seq, scCUT&Tag]

Single-nucleus multiomic mapping of m6A methylome and transcriptome in native populations of cells with sn-m6A-CT

A Lactate-induced SREBF2-dependent genetic program drives an immunotolerant dendritic cell population during cancer progression

Targeting T cell plasticity by pooled single cell CRISPR-screening in preclinical models of kidney and gut inflammation

Transcriptional and functional architecture of the whole neutrophil compartment

Impaired proteolysis of non-canonical RAS proteins drives clonal hematopoietic transformation

Dissecting developmental disorders caused by CTCF mutation at R567