ChromaFold predicts the 3D contact map from single-cell chromatin accessibility

High-content single-cell combinatorial indexing

Transcriptomics of skin reveal potential molecular mechanisms of psoriasis

Robust RNA editing via recruitment of endogenous ADARs using circular guide RNAs 

Targeting lipid metabolism in pancreatic cancer

Single-nucleus multiomic mapping of m6A methylome and transcriptome in native populations of cells with sn-m6A-CT [scRNA-seq, scCUT&Tag]

Impaired proteolysis of non-canonical RAS proteins drives clonal hematopoietic transformation

Genome editing by dual nucleases records deep lineage hierarchy with high fidelity.

The Inflammaging Microenvironment Induces Dysfunctional Rewiring of Tfh Cell Differentiation

A Lactate-induced SREBF2-dependent genetic program drives an immunotolerant dendritic cell population during cancer progression

Concurrent profiling of multiscale 3D genome organization and gene expression in single mammalian cells

RNA helicase DHX15 exemplifies a unique dependency in acute leukemia

Tau aggregates are RNA-protein assemblies that mis-localize multiple nuclear speckle components

In vivo adenine base editing of PCSK9 in mice and macaques reduces LDL-cholesterol levels [RNA-seq]

heart healthy and heart diseased SCGs

m6Am RNA methyltransferases PCIF1 regulate tumorigenesis of colorectal cancer and its immune responses to anti-PD-1 therapy

Atf3 controls transitioning in female mitochondrial cardiomyopathy as identified by single-cell transcriptomics

Dual nuclease single-cell lineage tracing by Cas9 and Cas12a

Self-reporting transposons enable simultaneous readout of gene expression and transcription factor binding in single cells

Joint epigenome profiling reveals cell-type-specific gene regulatory programs in human cortical organoids