Targeting Duchenne Muscular Dystrophy by Skipping DMD Exon 45 with Base Editors

SPLICER: A Highly Efficient Base Editing Toolbox That Enables in vivo Exon Skipping For Targeting Alzheimer’s Disease

In vivo CRISPR base editing for treatment of Huntington’s disease

Genome-wide CRISPR guide RNA design and specificity analysis with GuideScan2

A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation

miRNA-target chimeras identified with CLEAR-CLIP reveal miRNA 3' end pairing as a major determinant of Argonaute binding in vivo [mouse cortex CLEAR-CLIP]

Determination of direct binding targets of Quaking RNA binding proteins

Megadomains and superloops form dynamically during X-chromosome inactivation but are dispensable for silencing and escape

Genetic models reveal cis and trans immune-regulatory activities for lincRNA-Cox2 in vivo (macrophages)

Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination

Epigenetic Enhancer Marks and Transcription Factor Binding Influence Vk Gene Rearrangement in Pre-B Cells and Pro-B Cells [VDJ-seq]

Epigenetic Enhancer Marks and Transcription Factor Binding Influence Vkappa Gene Rearrangement in Pre-B Cells and Pro-B Cells

CtIP is essential for early B cell proliferation and development in mice

Phosphorylation at the S2056 1 cluster of DNA-PKcs is dispensable for lymphocyte development and class switch recombination in mice.

Indel rate analysis:Start codon disruption with CRISPR/Cas9 prevents murine Fuchs' endothelial corneal dystrophy

DNA-PKcs phosphorylation at the T2609 cluster alters the repair pathway choice during immunoglobulin class switch recombination

CtIP-mediated DNA resection is dispensable for IgH class switch recombination by alternative end-joining

T cell receptor is required for differentiation but not maintenance of intestinal CD4+ intraepithelial lymphocytes

Dnmt1 has global de novo methylation activity and is specifically targeted to transposable elements

FATC domain deletion compromises ATM protein stability, lymphocyte development, and promotes lymphomagenesis