Nuclear Factor NFAT5 Governs Cellular Plasticity-Induced KRAS-Targeted Therapy Resistance in Pancreatic Cancer

Genome access is transcription factor specific and defined by nucleosome position

ZNF143 is a transcriptional regulator of nuclear-encoded mitochondrial genes that acts independently of looping and CTCF

Age-associated chromatin re-organization in progenitor B cells

Kdm1a safeguards the topological boundaries of PRC2-repressed genes and prevents aging-related euchromatinization in neurons

NFIA in adipocytes reciprocally regulates mitochondrial and inflammatory gene program to improve glucose homeostasis

Methyl-CpG binding domain 2 (Mbd2) is an Epigenetic Regulator of Autism-Risk Genes and Cognition

Enhancers of the PAIR4 regulatory module promote distal VH gene recombination at the Igh locus

Igh and Igk loci use different folding principles for V gene recombination due to distinct chromosomal architectures of pro-B and pre-B cells

Induction of autoreactive regulatory T cells through promiscuous gene expression by bone marrow-resident Aire+ antigen-presenting cells

Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells

Screening thousands of transcribed coding and non-coding regions reveals sequence determinants of RNA polymerase II elongation potential.

Distinct MUNC lncRNA structural domains regulate transcription of different promyogenic factors [ChIRP-seq]

GLI transcriptional repression is inert prior to HH pathway activation

The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by pausing POL II at pro-differentiation genes

Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development

A cis-acting mechanism mediates trancriptional memory at Polycomb target genes in mammals

A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions

Epigenetic dysregulation impairs high-fidelity DNA repair to promote cerebellar degeneration in spinocerebellar ataxia type 7

NFIA differentially controls adipogenic and myogenic gene program through distinct pathways to ensure adipocyte differentiation